Multipolymer microsphere delivery of SARS-CoV-2 antigensArticle Published on 2023-03-012023-07-11 Journal: Acta biomaterialia [Category] COVID19(2023년), [키워드] antiviral immunity Multilayerpolymer Polymeric microspheres SARS-CoV-2 Slow-controlled antigen release. [DOI] 10.1016/j.actbio.2022.12.043 PMC 바로가기
Host microRNAs exhibit differential propensity to interact with SARS-CoV-2 and variants of concernArticle Published on 2023-02-012023-07-11 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), [키워드] antiviral immunity MicroRNAs post-transcriptional regulation SARS-CoV-2 variants of concern. [DOI] 10.1016/j.bbadis.2022.166612 PMC 바로가기
Synthetic Stimulator of Interferon Genes (STING) Agonists Induce a Cytokine-Mediated Anti-Hepatitis B Virus Response in Nonparenchymal Liver CellsArticle Published on 2023-01-132023-06-11 Journal: ACS Infectious Diseases [Category] B형 간염, [키워드] antiviral immunity Chronic Hepatitis B cytokine HBV-persistent mouse model nonparenchymal liver cells. STING [DOI] 10.1021/acsinfecdis.2c00424 PMC 바로가기
SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2DArticle Published on 2022-12-272023-07-11 Journal: Cell Reports [Category] COVID19(2023년), [키워드] antiviral immunity COVID-19 CP: Immunology CP: Microbiology Immune escape Innate immunity natural killer cells. NK cells NKG2D nsp1 SARS-CoV-2 [DOI] 10.1016/j.celrep.2022.111892 PMC 바로가기
Porcine deltacoronavirus E protein induces interleukin-8 production via NF-κB and AP-1 activationArticle Published on 2022-11-012022-11-15 Journal: Veterinary microbiology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] abrogated activated activating Activation acute respiratory syndrome Alpha antiviral immunity AP-1 binding C-terminal domain caused chemokine coronavirus coronavirus disease COVID-19 Cytokine release syndrome deleting demonstrated dependent on domain E E protein expression facilitate help IL-6 IL-8 induce Infection Inflammation inhibitor interleukin-6 IκBα life-threatening Local molecular mechanism motif NF-κB NF-κB pathway nuclear nuclear translocation p65 Pathogenesis PDCoV. Phosphorylation Proinflammatory cytokine promoter protein phosphorylation resulting SARS-CoV-2 Severe case upregulated [DOI] 10.1016/j.vetmic.2022.109553 PMC 바로가기
Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregatesArticle Published on 2022-10-052022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] absence activated Activation aggregate aggregates analysed antiviral immunity Blood blood cell CD107a CD62P Cell cells changes in chemokines Cohort correlated COVID-19 COVID-19 disease COVID-19 patient cytokine Cytokines Cytometry cytotoxicity discharged disease pathology early stage Ex vivo Features flow cytometry form Frequency gene signature hospital hospitalised hospitalised COVID-19 patient ICU ICU patient IFN-γ IL-15 in vitro increased expression Infection innate immune response intensive care unit killing majority natural Neutrophils NK cell NK cells Patient patients phenotype phenotyped plasma Platelet platelet aggregates. Platelets Post-COVID-19 patients quantified SARS-CoV-2 scRNA-seq severe COVID-19 disease severe symptoms Single-cell RNA-sequencing Stage subset Symptom Symptoms target cells the timing TNF-α viral infections were measured while [DOI] 10.3389/fimmu.2022.861251 PMC 바로가기
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificityArticle Published on 2022-10-032022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] airway analyzed antiviral immunity Breakthrough infection CD4+ T cell CD8+ COVID-19 COVID-19 vaccinee feature highlight Immunity immunological induce Infection nasal nasal mucosa persistence phenotype Primary infection Rapid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 vaccination SARS-CoV-2-infected cell specificity suppress T cell T cell response vaccination vaccinee [DOI] 10.1084/jem.20220780 PMC 바로가기
Multi-scale mechanism of antiviral drug-alike phytoligands from Ayurveda in managing COVID-19 and associated metabolic comorbidities: insights from network pharmacologyArticle Published on 2022-10-012022-11-15 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral drugs antiviral immunity APCS approach Ayurveda binding affinity cardiovascular complications Comorbidities Comorbidity COVID-19 creating develop Diabetes Mellitus disorders effective highlighting Host hypertension immunomodulators investigated mechanism molecular docking network network pharmacology novel coronavirus disease Protein target public health regulate Regulatory SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2. synergistic therapy Traditional virus Wuhan, China [DOI] 10.1007/s11030-021-10352-x PMC 바로가기
Social connection and gene regulation during the COVID-19 pandemic: Divergent patterns for online and in-person interactionArticle Published on 2022-10-012022-11-15 Journal: Psychoneuroendocrinology [Category] 치료제, [키워드] absence analyzed antibody production antiviral immunity antiviral response association blood sample characterized connection conserved COVID-19 COVID-19 pandemic CTRA disease risk down-regulation Effect eudaimonia examined experience Factors female Gene Expression Health healthy Immune cell immune system Interaction Linear model loneliness measure Multiple offset Online social interaction profile proinflammatory gene quantified question reduced Regulation RNA Social genomics. social interaction transcriptional response [DOI] 10.1016/j.psyneuen.2022.105885 PMC 바로가기
Mechanisms of CD8+ T-cell failure in chronic hepatitis E virus infectionArticle Published on 2022-10-012023-06-12 Journal: Journal of hepatology [Category] E형 간염, [키워드] antiviral immunity CD8+ T-cell response Immunological memory T-cell exhaustion viral escape. [DOI] 10.1016/j.jhep.2022.05.019 PMC 바로가기